In season 3, Clark and Lois are now working at the Smallville Gazette together and enjoying small town life. However, Lois' work-life balance is put to the test when an undercover assignment reveals a deadly foe that promises to change the Kent family forever. Meanwhile, the Kent boys find themselves being pulled in opposite directions as Jordan discovers what a superhero-identity really means and Jonathan searches for purpose beyond the football field. Amid all this upheaval, John Henry is haunted by his doppelgänger's past, leading to dangerous consequences for him and Natalie.

Following an action-packed and dramatic season three finale, the Kent family continues their fight against their biggest enemies in the upcoming final season. With Lois still reeling from her battle with cancer and Lex Luthor and his proxy Bizzarro-turned-Doomsday still a threat to Smallville and Superman, viewers are left hanging on edge amid this epic intergalactic battle in space.